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The Buffalo Bills face the New England Patriots in a pivotal Week 5 'Sunday Night Football' matchup with a chance to extend their AFC East lead. A win would put the Bills (4-0) three games ahead of the Patriots (2-2). SportsLine's AI is heavily backing Buffalo, predicting they'll cover the 8.5-point spread and win convincingly. The AI utilizes advanced machine learning from historical data and matchup analysis to provide betting recommendations for all Week 5 games, with over 2,000 4.5- and 5-star prop picks since 2023.

Prepared by Emily Rhodes and reviewed by editorial team.