Florio and Simms offer their Week 4 NFL game predictions. Simms holds a slight edge in the season's straight-up picks (29-19 vs. Florio's 36-12), while Florio leads against the spread (26-22 vs. Simms' 19-29). Their picks diverge on several key matchups, including Seahawks vs. Cardinals, Vikings vs. Steelers, and Ravens vs. Chiefs, among others. Both analysts emphasize responsible gambling.

Prepared by Emily Rhodes and reviewed by editorial team.