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49ers quarterback Brock Purdy is expected to miss at least two games, possibly up to five, due to a toe injury, according to reports. His absence will likely extend beyond this Sunday's game against the Saints and include the Week 3 matchup against Arizona. The team hasn't placed Purdy on injured reserve, suggesting a potential return within four games. Backup quarterback Mac Jones will start in Purdy's place, leading an offense already missing key players Brandon Aiyuk and George Kittle.

Prepared by Emily Rhodes and reviewed by editorial team.