Matthew Stafford tossed his 400th career touchdown and finished with four scores as the Rams blew out the 49ers 42-26. Stafford went 24-of-36 for 280 yards, extending his streak to 20 touchdowns and no interceptions over five games and a league-best 25 this season. He hit Puka Nacua, Davis Allen, Davante Adams and Colby Parkinson, while Kyren Williams ran for two TDs. Los Angeles led 21-0 and piled up 401 yards. San Francisco totaled 393 behind Mac Jones but had two turnovers. The Rams moved to 7-2; the 49ers fell to 6-4.

Prepared by Emily Rhodes and reviewed by editorial team.