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Week 5 of the NFL season presents betting opportunities despite bye weeks and injuries. Key matchups include Colts vs. Raiders and Bills vs. Patriots. SportsLine's expert handicappers offer valuable picks and predictions for spreads and props. Notable experts like Matt Severance, Doug "Prop Bet Guy" Kralstein, and Daniel Vithlani share their top selections, with Severance recommending Over 22.5 points for the Jets, Kralstein backing Woody Marks for receiving yards, and Vithlani predicting David Montgomery as an anytime touchdown scorer.

Prepared by Emily Rhodes and reviewed by editorial team.