The Buffalo Bills aim to extend their AFC East lead against the New England Patriots in Week 5. A Bills victory would give them a three-game divisional advantage. SportsLine's AI predicts the Bills will cover the 8.5-point spread and win comfortably, rating the pick as A+. The AI also forecasts a 34-19 win for Buffalo, highlighting Josh Allen's strong performance.

Prepared by Emily Rhodes and reviewed by editorial team.