The San Francisco 49ers narrowly defeated the Los Angeles Rams 26-23 in overtime, despite a significant number of injuries. Quarterback Mac Jones played through ailments, throwing for 342 yards and two touchdowns. The 49ers' defense made crucial plays, including a fumble recovery at the 1-yard line. Eddy Piniero secured the win with a 41-yard field goal in overtime. Despite the loss, Rams receiver Puka Nacua set an NFL record for most receptions through five games.

Prepared by Emily Rhodes and reviewed by editorial team.