The Los Angeles Rams host the San Francisco 49ers on Thursday Night Football, with both teams holding a 3-1 record. The 49ers suffered their first loss to the Jaguars, while the Rams secured their third win against the Colts. San Francisco faces significant player absences, including Brock Purdy. The Rams are favored by 8.5 points, and the SportsLine model predicts an over on the total points. Betting lines and promo codes are also highlighted for potential bettors.

Prepared by Emily Rhodes and reviewed by editorial team.