Week 5 of the NFL season features fewer games due to byes, presenting opportunities for focused betting. Key matchups include inter-conference clashes like Jets vs. Cowboys and Broncos vs. Eagles. A notable divisional game sees the Bills hosting the Patriots. SportsLine's advanced computer model offers predictions and betting advice, highlighting strong picks for Saints vs. Giants and Cardinals vs. Titans, along with top-rated plays for other games.

Prepared by Emily Rhodes and reviewed by editorial team.