In an NFL Week 5 preview, analysts Florio and Simms reveal their game picks, highlighting potential dramatic shifts in standings. Florio leads Simms in straight-up and against-the-spread records for the season. Their differing predictions span matchups like 49ers vs. Rams and Vikings vs. Browns, with advice offered to betters to wager responsibly and treat it as entertainment.

Prepared by Emily Rhodes and reviewed by editorial team.