Week 5 of college football boasts numerous high-stakes matchups, including four ranked team clashes. The article highlights six key games, offering betting predictions. Oregon (+3.5) against Penn State is favored, despite Penn State's home advantage. The over (52.5) is predicted for Alabama vs. Georgia, anticipating a high-scoring affair. USC (-6.5) is slated to defeat Illinois, despite Illinois's injuries. The under (44.5) is favored for Rice vs. Navy, given both teams' run-heavy offenses. Notre Dame's team total (over 34.5) is predicted due to Arkansas's weak defense. Finally, Kentucky (+205) is viewed as an upset winner against South Carolina.

Prepared by Emily Rhodes and reviewed by editorial team.