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Texans vs. Buccaneers prediction, odds, time: 2025 NFL Week 2 Monday Night Football picks from proven model

The Houston Texans and Tampa Bay Buccaneers face off in a Monday Night Football matchup. The Texans, seeking their first win after a Week 1 loss, host the victorious Buccaneers. Key receivers Christian Kirk (Texans) and Chris Godwin (Buccaneers) are sidelined due to injury. Houston is a 2.5-point favorite, with the over/under set at 42.5 points. A sports model predicts the game's outcome, suggesting one side of the spread has a nearly 60% chance of success and favors the over.

Prepared by Emily Rhodes and reviewed by editorial team.

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