The Philadelphia Eagles, defending Super Bowl champions, host the Dallas Cowboys in the 2025 NFL season opener. This marks the first time these NFC East rivals have opened a season against each other since 2000. The Eagles are favored by 8.5 points, the largest spread for a defending champion in a kickoff game since 2021. While Philadelphia swept the series last year, Dallas' Dak Prescott has a strong record against the Eagles.

Prepared by Emily Rhodes and reviewed by editorial team.