The 2025 NFL season kicks off with the Eagles defending their Super Bowl title against the Cowboys. An NFL projection model predicts four best bets for Week 1: Under 45.5 points for Giants-Commanders, under 48 points for Bengals-Browns, over 43.5 points for 49ers-Seahawks, and Texans +3 against the Rams (fading Stafford's injury). The model's past performance shows a mixed record, and the author advises shopping for the best odds. A teaser bet combines Eagles -2.5 and Broncos -2.5.

Prepared by Emily Rhodes and reviewed by editorial team.