The Detroit Lions opened their 2025 NFL preseason against the Los Angeles Chargers in the Hall of Fame Game. Neither team started veteran players, giving opportunities to younger players vying for roster spots. The Chargers dominated the first half, leading 21-7 at halftime, due largely to Lions special teams miscues and turnovers. The Lions showed some offensive flashes, particularly rookie receiver Isaac TeSlaa, but ultimately fell behind. The game served as an important evaluation tool for both teams' fringe players.

Prepared by Emily Rhodes and reviewed by editorial team.