Rosie O'Donnell revealed a significant weight loss, attributing it to Mounjaro, a type 2 diabetes medication, and lifestyle changes. Two years after initially discussing her use of Mounjaro, she shared a photo showcasing her transformation. O'Donnell, who has openly discussed past weight struggles, credits the medication, along with giving up sugary drinks and cooking for herself instead of using a chef, for her improved health and sleep. She now finds shopping for clothes in a smaller size shocking after years of wearing elastic pants.

Prepared by Olivia Bennett and reviewed by editorial team.